Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Interference01:23

RNA Interference

26.8K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.8K
Types of RNA01:23

Types of RNA

69.7K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
69.7K
Translational Regulation01:29

Translational Regulation

279
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
279
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.1K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.1K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

13.8K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
13.8K
RNA Structure01:19

RNA Structure

5.6K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.

Genes & development·2026
Same author

Loss of HOXA10 activates NLRP3 for epithelial plasticity and pyroptosis in endometrium during embryo implantation.

Reproduction (Cambridge, England)·2026
Same author

Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes.

bioRxiv : the preprint server for biology·2025
Same author

A novel circRNA-miRNA-mRNA regulatory axis as a sex-specific biological variable in bronchopulmonary dysplasia.

NAR molecular medicine·2025
Same author

HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation.

Cell death discovery·2025
Same author

Circular RNA <i>Pde4dip</i> regulates myogenesis by interacting with <i>Zfp143</i> mRNA: a novel regulatory axis.

RNA biology·2025

Related Experiment Video

Updated: Oct 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K

Emerging Role of Circular RNA-Protein Interactions.

Arundhati Das1,2, Tanvi Sinha1, Sharmishtha Shyamal1

  • 1Institute of Life Sciences, Nalco Square, Bhubaneswar 751023, India.

Non-Coding RNA
|August 27, 2021
PubMed
Summary

Circular RNAs (circRNAs) interact with RNA-binding proteins (RBPs) to regulate gene expression. This review explores emerging mechanisms and functional roles of these circRNA-protein interactions in cell physiology.

Keywords:
RNA-binding proteincircRNAdecoymRNA stabilitysplicingtranslation

More Related Videos

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.5K

Related Experiment Videos

Last Updated: Oct 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.5K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are key regulators of gene expression.
  • RNA-binding proteins (RBPs) are crucial for modulating gene expression.
  • Interactions between circRNAs and RBPs are a recent area of research.

Purpose of the Study:

  • To review the emerging mechanisms of circRNA-protein interactions.
  • To outline the functional roles of circRNA-RBP interactions in cell physiology.

Main Methods:

  • Literature review of high-throughput RNA-protein interaction data.
  • Analysis of studies investigating circRNA-RBP binding.
  • Synthesis of current understanding of circRNA-RBP functional implications.

Main Results:

  • CircRNAs interact with RBPs, influencing downstream gene expression.
  • RBPs modulate RNA splicing, export, stability, localization, and translation.
  • CircRNA-protein interactions can alter protein interactions with target mRNAs or proteins.

Conclusions:

  • CircRNA-RBP interactions represent a novel layer of gene regulation.
  • Understanding these interactions is crucial for comprehending cell physiology.
  • Further research into circRNA-protein interactions will uncover new biological insights.