Related Experiment Video
Updated: Oct 22, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Relative Contribution of Genetic and Environmental Factors in CKD
Derek E Lee1, Mohammad Qamar1, Russell A Wilke1
1Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Abstract:
Chronic kidney disease affects nearly 15 percent of the U.S. population. Onset and rate of progression are influenced by a combination of genetic and non-genetic factors. Because health care systems across the U.S. are beginning to deploy automated decision support to stratify patients at risk, we review the relative impact of genetic factors (e.g., APOL1 gene polymorphisms) and non-genetic factors (e.g., clinical comorbidities and exposure to environmental nephrotoxins) contributing to this common disease. Overall, the impact of non-genetic factors appears to exceed the impact of genetic factors.
Related Concept Videos
Chronic Kidney Disease I: Introduction
Gene-Environment Interactions
Chronic Kidney Disease III: Interprofessional Care
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Chronic Kidney Disease II: Clinical Manifestations
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

