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Updated: Oct 22, 2025

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Post-transcriptional regulation in attaching and effacing pathogens: integration of environmental cues and the impact
Sarah Smallets1, Melissa M Kendall2
1Department of Biology, University of Virginia, 485 McCormick Rd., Charlottesville, VA, 22904, USA.
Abstract:
To establish infection, enteric pathogens integrate environmental cues to navigate the gastrointestinal tract and precisely control expression of virulence determinants. Emerging data indicate that post-transcriptional and post-translational gene regulation plays a key role in virulence regulation and pathogen adaptation to the host environment. Here, we highlight recent studies that reveal how physiologically relevant signals initiate post-transcriptional and post-translational regulatory circuits and the impact on virulence gene expression in the attaching and effacing pathogens, enteropathogenic Escherichia coli, enterohemorrhagic E. coli O157:H7, and Citrobacter rodentium.
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