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Related Concept Videos

Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

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The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
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Residual Stresses in Bending01:18

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In the study of elastoplastic members subjected to bending moments, understanding the loading and unloading phases is crucial for assessing material behavior and structural integrity. During the loading phase, as the bending moment increases, the material initially responds elastically, adhering to Hooke's Law, where stress is directly proportional to strain. When the load exceeds the yield strength, plastic deformation occurs, resulting in permanent strain and deformation that remains even...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

221
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Related Experiment Video

Updated: Oct 22, 2025

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Viscoelastic Behavior of Drug-Loaded Polyurethane.

Navideh Abbasnezhad1,2, Mohammadali Shirinbayan1,2, Fatiha Chabi1

  • 1Arts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, France.

Polymers
|August 28, 2021
PubMed
Summary

Understanding how drug loading affects polyurethane (PU) drug carriers is crucial for stent coatings. Increased drug load and release enhance porosity and alter release kinetics, impacting stent performance and patient safety.

Keywords:
drug deliverydrug-eluting stent (DES)flow ratemechanical propertiespolyurethaneviscoelastic properties

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Engineering

Background:

  • Drug-eluting stents (DES) are vital for localized drug delivery, but drug incorporation impacts polymer properties.
  • Mechanical stresses on polymer coatings during stent deployment can lead to therapeutic failure.
  • A deeper understanding of drug-polymer interactions under physiological conditions is needed.

Purpose of the Study:

  • To investigate the influence of drug loading and release on the physicochemical properties of polyurethane (PU) drug carriers.
  • To evaluate the behavior of PU drug carriers in phosphate-buffered saline (PBS) under stagnant and circulating conditions.
  • To establish relationships between drug release, mechanical properties, and viscoelastic behavior.

Main Methods:

  • Fabrication of in-house polyurethane (PU) drug carriers loaded with diclofenac epolamine.
  • Dynamic Mechanical Thermal Analysis (DMTA) for viscoelastic properties.
  • Tensile testing to assess mechanical strength (Young's modulus, ultimate stress).
  • Monitoring drug release kinetics in PBS under different flow conditions.

Main Results:

  • Increased drug loading and release time led to higher free volume fraction and pore count in PU samples.
  • Drug release kinetics were accelerated by higher drug loading ratios and the presence of fluid flow.
  • Young's modulus and ultimate stress remained largely unaffected by drug release time.
  • A correlation was established between tensile properties and the viscoelastic behavior of the drug-loaded PU.

Conclusions:

  • Drug loading significantly impacts the microstructure and drug release profiles of PU carriers.
  • The mechanical integrity of the PU coating is maintained during drug release.
  • These findings are critical for optimizing drug coating performance in drug-eluting stents.