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Laser-Induced Graphene-Based Enzymatic Biosensor for Glucose Detection.

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|August 28, 2021
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This study introduces a flexible laser-induced graphene (LIG) biosensor for glucose detection. The cost-effective LIG biosensor demonstrates high sensitivity and selectivity, offering a promising tool for rapid glucose monitoring.

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Area of Science:

  • Materials Science
  • Electrochemistry
  • Biosensor Technology

Background:

  • Laser-induced graphene (LIG) is gaining attention for its cost-effective and straightforward fabrication.
  • Electrochemical biosensors are crucial for detecting various analytes, including glucose.

Purpose of the Study:

  • To develop a flexible, laser-induced graphene-based electrochemical biosensor for glucose detection.
  • To evaluate the performance of the developed biosensor in terms of sensitivity, selectivity, and detection limit.

Main Methods:

  • Fabrication of a laser-induced graphene electrode (LIGE) on a polyimide substrate using a 450 nm UV laser.
  • Immobilization of a chitosan-glucose oxidase (GOx) composite onto the LIGE surface.
  • Amperometric detection of glucose and interference studies with common interfering compounds.

Main Results:

  • The LIGE biosensor exhibited a wide linear range for glucose detection up to 8 mM.
  • High sensitivity of 43.15 µA mM⁻¹ cm⁻² and a low detection limit of 0.431 mM were achieved.
  • The biosensor showed no interference from ascorbic acid, uric acid, and urea, indicating high selectivity.

Conclusions:

  • The developed laser-induced graphene electrode (LIGE) biosensor is a simple and low-cost platform for glucose detection.
  • The biosensor offers rapid, sensitive, and selective glucose monitoring capabilities.
  • This technology holds potential for practical applications in diagnostics and health monitoring.