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Transcranial Focal Electrical Stimulation Modifies Biogenic Amines' Alterations Induced by 6-Hydroxydopamine in Rat
Cesar Emmanuel Santana-Gómez1, Daniel Pérez-Pérez2, Daniel Fonseca-Barriendos3
1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Pharmaceuticals (Basel, Switzerland)
|August 28, 2021
Summary
Repetitive transcranial focal stimulation (TFS) can prevent changes in brain biogenic amines caused by 6-hydroxydopamine (6-OHDA) neurotoxicity. This neuromodulation strategy offers potential therapeutic benefits against neurodegenerative effects.
Area of Science:
- Neuroscience
- Neuromodulation
- Neuropharmacology
Background:
- 6-hydroxydopamine (6-OHDA) induces nigrostriatal neurodegeneration, altering dopamine, serotonin, and histamine levels.
- Transcranial focal stimulation (TFS) is a non-invasive neuromodulation technique with demonstrated neuroprotective properties.
Purpose of the Study:
- To investigate if repetitive TFS can counteract the biogenic amine alterations induced by 6-OHDA neurotoxicity.
- To assess the impact of TFS on dopamine, serotonin, and histamine levels in various brain regions following 6-OHDA injection.
Main Methods:
- Animals received intrastriatal 6-OHDA injections followed by daily TFS for 21 days.
- Tissue content of dopamine, serotonin, and histamine was measured in the cerebral cortex, hippocampus, amygdala, and striatum.
- Results were compared across groups: 6-OHDA + TFS, 6-OHDA only, TFS only, and Sham.
Main Results:
- TFS did not prevent dopamine level changes in the striatum post-6-OHDA.
- However, TFS successfully mitigated several 6-OHDA-induced alterations in dopamine, serotonin, and histamine across evaluated brain areas.
- TFS alone did not cause significant changes in biogenic amine levels.
Conclusions:
- Repetitive TFS effectively counteracts neurochemical imbalances caused by 6-OHDA-induced neurotoxicity.
- TFS presents a promising therapeutic strategy for mitigating neurotoxicity and preserving biogenic amine homeostasis in neurodegenerative conditions.
