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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
511
Extracellular Vesicles in Skin Wound Healing
Deimantė Narauskaitė1, Gabrielė Vydmantaitė1, Justina Rusteikaitė2
1Laboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.
Pharmaceuticals (Basel, Switzerland)
|August 28, 2021
Summary
Extracellular vesicles (EVs) are crucial for natural wound healing and can be engineered for therapeutic applications in skin repair and dermal disease treatment. This review explores their role in wound healing and regenerative medicine.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Dermatology
Background:
- Millions suffer from non-healing wounds, scarring, and infected injuries annually.
- Extracellular vesicles (EVs) show promise as novel therapeutic interventions.
- EVs naturally participate in all four phases of wound healing: hemostasis, inflammation, proliferation, and remodeling.
Purpose of the Study:
- To summarize current knowledge on the natural role of EVs in skin repair.
- To highlight recent findings on EV applications in wound healing, skin regeneration, and dermal disease treatment.
- To promote scientific awareness in basic and translational research of EVs.
Main Methods:
- Review of existing scientific literature on extracellular vesicles and wound healing.
- Analysis of the natural functions of EVs in each stage of skin repair.
- Examination of engineered EVs, including stem cell-derived and plant-derived sources.
Main Results:
- EVs play an integral role in natural skin repair processes.
- EVs can be engineered to carry specific cargo and target specific cells for enhanced therapeutic effects.
- Applications include wound healing, skin regeneration, and treatment of various dermal conditions.
Conclusions:
- EVs offer a promising platform for developing advanced therapies for skin injuries and diseases.
- Further research into engineered EVs can optimize their therapeutic potential.
- EV-based therapies represent a significant advancement in regenerative medicine and dermatology.
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