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Related Concept Videos

Coordination Compounds and Nomenclature02:54

Coordination Compounds and Nomenclature

In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Immunogold Electron Microscopy01:20

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Complexometric Titration: Ligands00:43

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Related Experiment Video

Updated: Jun 30, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
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Labelling via [Al18F]2+ Using Precomplexed Al-NODA Moieties.

Daniel Kang1, Ulrich Simon1, Felix M Mottaghy2,3

  • 1Institute of Inorganic Chemistry, RWTH Aachen University, 52056 Aachen, Germany.

Pharmaceuticals (Basel, Switzerland)
|August 28, 2021
PubMed
Summary

A new two-step method for fluorine-18 (18F) radiopharmaceutical synthesis offers improved yields. This approach avoids free aluminum ions, potentially overcoming limitations of current Gallium-68 (68Ga) methods.

Keywords:
[Al18F]2+ cationaqueous [18F]fluoride labellingchelator labellingreaction optimization

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Area of Science:

  • Radiochemistry
  • Nuclear Medicine
  • Pharmaceutical Chemistry

Background:

  • Gallium-68 (68Ga) radiopharmaceuticals are vital in clinical settings but face supply limitations.
  • Existing 18F labeling methods often use one-pot syntheses with free aluminum ions.

Purpose of the Study:

  • To develop a novel two-step synthesis for 18F radiopharmaceuticals using aqueous [Al18F]2+.
  • To investigate and optimize parameters for this two-step labeling approach.

Main Methods:

  • A two-step synthesis was developed, separating precursor generation from the labeling step.
  • The model chelator NH2-MPAA-NODA was used to study the impact of temperature, pH, organic solvent, and reaction time.
  • The labeling utilized aqueous [18F]fluoride with no free Al3+ ions present.

Main Results:

  • Optimized conditions yielded a stable 80% radiochemical yield.
  • A reaction time of 30 minutes at 100 °C was sufficient for high yields.
  • The two-step method demonstrated efficient aqueous labeling with 18F.

Conclusions:

  • This two-step approach for 18F radiopharmaceutical synthesis shows significant promise.
  • It offers a potential alternative to 68Ga generators by overcoming supply and yield limitations.
  • The technique is adaptable and could become a key method in radiopharmaceutical development.