Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rationale and current status of fecal microbiota transplantations for Parkinson's disease.

Journal of Parkinson's disease·2026

Same author

Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy.

Nature communications·2026

Same author

Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles.

Journal of extracellular vesicles·2026

Same author

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF.

Nature neuroscience·2026

Same author

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.

Nature communications·2025

Same author

Challenging the conventional wisdom: Re-evaluating Smpd3's role in extracellular vesicle biogenesis.

Journal of extracellular biology·2024

Search research articles

Related Experiment Video

Updated: Oct 22, 2025

Isolation of Low Endotoxin Content Extracellular Vesicles Derived from Cancer Cell Lines

Isolation of Low Endotoxin Content Extracellular Vesicles Derived from Cancer Cell Lines

Published on: February 17, 2023

Extracellular Vesicles: A Double-Edged Sword in Sepsis.

Marlies Burgelman^1,2, Charysse Vandendriessche^1,2, Roosmarijn E Vandenbroucke^1,2

¹VIB Center for Inflammation Research, 9052 Ghent, Belgium.

Pharmaceuticals (Basel, Switzerland)

|August 28, 2021

Summary

Extracellular vesicles (EVs) levels change during sepsis, impacting inflammation, cell death, and organ function. Understanding EV roles is crucial for predicting sepsis outcomes and developing treatments.

Keywords:

extracellular vesicles inflammation sepsis

More Related Videos

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

Related Experiment Videos

Last Updated: Oct 22, 2025

Isolation of Low Endotoxin Content Extracellular Vesicles Derived from Cancer Cell Lines

Isolation of Low Endotoxin Content Extracellular Vesicles Derived from Cancer Cell Lines

Published on: February 17, 2023

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

Area of Science:

Sepsis research
Extracellular vesicle biology
Immunology

Background:

Sepsis involves life-threatening organ dysfunction due to infection.
Extracellular vesicle (EV) levels are altered in sepsis patients and mouse models.
The precise roles of EVs in sepsis pathology remain incompletely understood.

Purpose of the Study:

To review current knowledge on the sources and functions of EVs in sepsis.
To synthesize findings from in vitro, mouse, and human studies.

Main Methods:

Literature review of studies on extracellular vesicles in sepsis.
Analysis of data from in vitro experiments.
Examination of findings from mouse models of sepsis.
Inclusion of data from human sepsis patient samples.

Main Results:

Sepsis-associated EVs modulate inflammation, lymphocyte apoptosis, coagulation, and organ dysfunction.
EVs can influence sepsis clinical outcomes and may serve as predictive biomarkers for survival.
Both beneficial and detrimental roles of EVs in sepsis have been reported, varying by EV source and disease stage.

Conclusions:

Extracellular vesicles play complex roles in sepsis pathogenesis.
Further research into EV sources and functions is needed to understand their full impact on sepsis.
EVs hold potential for predicting sepsis prognosis and guiding therapeutic strategies.