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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Vaccinations01:51

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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Cross-reactivity00:42

Cross-reactivity

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Active versus Passive Immunity01:31

Active versus Passive Immunity

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Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
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Related Experiment Video

Updated: Oct 22, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Vaccinations and Autoimmune Diseases.

Bianca Olivieri1, Corrado Betterle2, Giovanna Zanoni3

  • 1Department of Medicine, School of Specialization in Allergy and Clinical Immunology, University of Verona, 37134 Verona, Italy.

Vaccines
|August 28, 2021
PubMed
Summary

Vaccines are safe and effective public health tools. While rare adverse events can occur, scientific evidence does not support vaccines causing autoimmune diseases, with few exceptions like Guillain-Barré syndrome and thrombocytopenia.

Keywords:
Guillain-Barré syndromeSARS-CoV2 vaccinesautoimmune diseasesautoimmunitythrombocytopeniavaccine-induced immune thrombotic thrombocytopeniavaccines

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Area of Science:

  • Immunology
  • Public Health
  • Vaccinology

Background:

  • Vaccines are crucial for public health, preventing diseases and saving lives.
  • Adverse Events Following Immunization (AEFI) can occur but are not always vaccine-related.
  • Autoimmune diseases are a significant concern regarding vaccine safety.

Purpose of the Study:

  • To review the scientific evidence on the relationship between vaccines and autoimmune diseases.
  • To address public concerns regarding vaccine-induced autoimmunity.
  • To highlight the safety surveillance of new vaccine technologies.

Main Methods:

  • Review of epidemiological studies and scientific literature.
  • Analysis of established vaccine safety data.
  • Examination of rare, confirmed vaccine-associated adverse events.

Main Results:

  • No demonstrated mechanisms link vaccines to the development of most autoimmune diseases.
  • Epidemiological data do not support vaccines causing systemic autoimmune diseases.
  • Rare associations exist, including Guillain-Barré syndrome with flu vaccines and thrombocytopenia with MMR vaccine.

Conclusions:

  • Current evidence indicates vaccines do not cause widespread autoimmune diseases.
  • Established rare risks are closely monitored.
  • Ongoing safety surveillance is critical for new vaccines, including those for SARS-CoV-2.