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The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer

Delphine Fessart1,2,3, Jacques Robert4, Cecile Hartog4

  • 1INSERM U1242, "Chemistry, Oncogenesis Stress Signaling", Université Rennes 1, Rennes, France. delphine.fessart@inserm.fr.

Journal of Experimental & Clinical Cancer Research : CR
|August 28, 2021
PubMed

Insights

Anterior gradient proteins AGR2 and AGR3 are implicated in epithelial ovarian cancer (EOC). Understanding their role may lead to new diagnostic and therapeutic strategies for this lethal gynecologic malignancy.

Area of Science:

  • Gynecology
  • Oncology
  • Molecular Biology

Background:

  • Epithelial ovarian cancer (EOC) is a leading cause of cancer death in women globally.
  • Despite therapeutic advances, EOC remains highly lethal, necessitating novel treatment strategies.
  • Anterior gradient (AGR) proteins, AGR2 and AGR3, are related to protein disulfide isomerase (PDI) and are implicated in adenocarcinoma development.

Purpose of the Study:

  • To review the current understanding of AGR family proteins in EOC.
  • To explore the expression patterns of AGR2 and AGR3 in EOC.
  • To discuss the potential clinical utility of AGR2 and AGR3 in EOC management.

Main Methods:

  • Literature review of studies on AGR proteins and EOC.
  • Analysis of existing data on AGR2 and AGR3 expression in EOC tissues.
  • Synthesis of information regarding the functional roles of AGR2 and AGR3 in cancer.

Main Results:

  • AGR2 and AGR3 are expressed in EOC and may play a role in its pathogenesis.
  • Expression levels of AGR2 and AGR3 could correlate with EOC diagnosis and patient outcomes.
  • AGR proteins represent potential targets for novel EOC therapies.

Conclusions:

  • The AGR family, particularly AGR2 and AGR3, is relevant to epithelial ovarian cancer.
  • Further research into AGR proteins could uncover new diagnostic biomarkers and therapeutic targets for EOC.
  • Targeting AGR family proteins may offer new avenues for managing EOC patients.
Keywords:
AGR2AGR3Endoplasmic reticulum proteinsEpithelial ovarian Cancer

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