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Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
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Epidemiology of scoliosis in cerebral palsy: A population-based study at skeletal maturity

Kate L Willoughby1,2, Soon Ghee Ang1, Pam Thomason2,3

  • 1Orthopaedic Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Journal of Paediatrics and Child Health
|August 28, 2021
PubMed

Insights

Scoliosis is common in individuals with cerebral palsy (CP), particularly those with severe motor impairments. Early screening and targeted surveillance are crucial for managing spinal curvature in this population.

Area of Science:

  • Orthopedics
  • Neurology
  • Pediatrics

Background:

  • Cerebral palsy (CP) affects motor function and is associated with various musculoskeletal complications.
  • Scoliosis, a spinal deformity, is a known complication in individuals with CP.
  • Understanding the prevalence and risk factors for scoliosis in CP is essential for effective management.

Purpose of the Study:

  • To determine the prevalence of scoliosis in a large, population-based cohort of individuals with cerebral palsy (CP) at skeletal maturity.
  • To identify risk factors associated with scoliosis in CP to inform surveillance strategies.

Main Methods:

  • A cohort of young people with CP born between 1990-1992 was reviewed.
  • CP classification included movement disorder, distribution, and motor function (GMFCS, MACS).
  • Spinal radiographs were used to measure scoliosis severity (Cobb angle).

Main Results:

  • Scoliosis (Cobb angle >10°) was present in 41% of 292 evaluated individuals.
  • Prevalence strongly correlated with Gross Motor Function Classification System (GMFCS) and Manual Abilities Classification System (MACS) levels, and dystonic/mixed movement disorders.
  • Individuals at GMFCS V were 23.4 times more likely to develop scoliosis; severe curves (>40°) were almost exclusively in GMFCS IV/V and associated with dystonia.

Conclusions:

  • Scoliosis is highly prevalent in young adults with CP.
  • Severity is significantly associated with GMFCS, MACS, and dystonic movement disorders.
  • Clinical screening for all CP patients and radiographic surveillance for those at GMFCS IV/V are recommended.
Abstract

Keywords:
GMFCSMACScerebral palsyscoliosissurveillance

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