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Updated: Oct 22, 2025

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
International consensus on the use of [18F]-FDG PET/CT in pediatric patients affected by epilepsy
Mei Tian1,2, Yasuyoshi Watanabe3, Keon Wook Kang4
1Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. meitian@zju.edu.cn.
Insights
This international consensus provides the first guideline for using 18F-fluorodeoxyglucose (FDG) PET/CT scans in children with epilepsy. It standardizes the precise localization of the epileptogenic focus in pediatric epilepsy patients.
Area of Science:
- Nuclear Medicine
- Pediatric Neurology
- Medical Imaging
Background:
- 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) is crucial for localizing the epileptogenic focus in epilepsy patients.
- Its application is expanding, particularly in pediatric epilepsy cases.
Purpose of the Study:
- To establish the first international consensus and practice guideline for brain 18F-FDG PET/CT in pediatric epilepsy.
- To provide specific considerations for utilizing 18F-FDG PET in pediatric epilepsy patients.
Main Methods:
- An international, multidisciplinary task group was formed to develop the guideline.
- The guideline covers clinical indications, patient preparation, radiopharmaceuticals, image acquisition, processing, interpretation, and reporting.
Main Results:
- The guideline for brain 18F-FDG PET/CT in pediatric epilepsy patients has been discussed and approved.
- This consensus establishes an international standard for clinical practice.
Conclusions:
- This document represents the first international consensus and practice guideline for brain 18F-FDG PET/CT in pediatric epilepsy.
- It aims to standardize and improve the clinical application of 18F-FDG PET/CT for pediatric epilepsy management.
Purpose:
Positron emission tomography (PET) with 18F-fluorodeoxyglucose ([18F]-FDG) has been increasingly applied in precise localization of epileptogenic focus in epilepsy patients, including pediatric patients. The aim of this international consensus is to provide the guideline and specific considerations for [18F]-FDG PET in pediatric patients affected by epilepsy.
Methods:
An international, multidisciplinary task group is formed, and the guideline for brain [18F]-FDG PET/CT in pediatric epilepsy patients has been discussed and approved, which include but not limited to the clinical indications, patient preparation, radiopharmaceuticals and administered activities, image acquisition, image processing, image interpretation, documentation and reporting, etc. CONCLUSION: This is the first international consensus and practice guideline for brain [18F]-FDG PET/CT in pediatric epilepsy patients. It will be an international standard for this purpose in clinical practice.
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