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Kidney implications of SARS-CoV2 infection in children

Erica C Bjornstad1, Michael E Seifert2, Keia Sanderson3

  • 1Department of Pediatrics, Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA. ebjornstad@uabmc.edu.

Pediatric Nephrology (Berlin, Germany)
|August 28, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) can affect children's kidneys, causing various issues. This review updates pediatric nephrologists on SARS-CoV2 kidney impacts and research gaps.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Virology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) impacts multiple organs, with varying severity.
  • Children generally experience milder SARS-CoV2 disease than adults, including those with pre-existing kidney conditions.

Purpose of the Study:

  • To provide an updated understanding of SARS-CoV2's effects on pediatric kidney health.
  • To identify knowledge gaps in pediatric nephrology concerning SARS-CoV2 infection.

Main Methods:

  • Literature review and synthesis of current research on SARS-CoV2 and pediatric kidney disease.
  • Analysis of clinical manifestations and outcomes in children with SARS-CoV2 and kidney involvement.

Main Results:

  • SARS-CoV2 can cause diverse kidney manifestations in children, including acute kidney injury and thrombotic microangiopathy.
  • Children with SARS-CoV2 may face increased risks of morbidity and mortality from kidney complications.
  • Clotting in extracorporeal circuits during kidney replacement therapy is a concern in infected children.

Conclusions:

  • SARS-CoV2 poses significant risks to pediatric kidney health, necessitating ongoing research.
  • Future research should address knowledge gaps, particularly concerning social disparities exacerbated by the pandemic.

Keywords:
Acute kidney injuryCOVID-19Chronic kidney diseaseDialysisEpidemiologyGlomerular diseasesPediatric nephrologySARS-CoV2Transplant

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