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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
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Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosis
Samreen Fatima1, Anjna Kumari1, Meetu Agarwal2
1Immunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
The FEBS Journal
|August 28, 2021
Summary
Tuberculosis bacteria use epigenetics to evade immune responses. Targeting these epigenetic changes offers a promising strategy for new host-directed therapies against tuberculosis (TB).
Area of Science:
- Molecular Biology
- Immunology
- Pathogenesis
Background:
- Tuberculosis (TB) remains a leading infectious cause of death worldwide.
- Mycobacterium tuberculosis (M.tb) employs epigenetic modifications to evade host immunity.
- Current anti-TB drugs face challenges of drug resistance, toxicity, and long treatment durations.
Purpose of the Study:
- To review the role of epigenetic alterations in TB pathogenesis.
- To discuss epigenetic-based therapeutic strategies for TB treatment.
- To highlight the potential of host-directed therapies targeting epigenetics.
Main Methods:
- Literature review of studies on epigenetics in TB.
- Analysis of M.tb's manipulation of host epigenome.
- Exploration of reversible epigenetic changes for therapeutic intervention.
Main Results:
- M.tb significantly impacts the host epigenome to favor pathogen survival.
- Epigenetic modifications alter immune gene expression, subverting host defenses.
- These host epigenome changes are reversible.
Conclusions:
- Epigenetic mechanisms are crucial in TB pathogenesis.
- Exploiting reversible epigenetic changes presents a viable avenue for novel host-directed therapies.
- Epigenetic therapies could offer effective TB treatment with reduced resistance and toxicity.
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