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Role of pyroptosis in cancer and its therapeutic regulation

Abdullah Al Mamun1, Anjuman Ara Mimi2, Md Abdul Aziz3

  • 1Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China.

European Journal of Pharmacology
|August 28, 2021
PubMed

Insights

Pyroptosis, a cell death process, is crucial in cancer development. Inducing pyroptosis offers a potential new therapy for managing various cancers.

Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • Pyroptosis is a programmed cell death pathway involving cellular lysis and inflammatory factor release.
  • This cell death mechanism is regulated by gasdermins.
  • Pyroptosis is gaining significant attention in clinical and research settings.

Purpose of the Study:

  • To review the molecular and morphological features of pyroptosis.
  • To explore the role of pyroptosis in various cancers.
  • To highlight the functions of GSDMD and GSDME in cancer.

Main Methods:

  • Literature review of pyroptosis and cancer studies.
  • Analysis of molecular and morphological characteristics of pyroptosis.
  • Examination of gasdermin family members (GSDMD, GSDME) in cancer.

Main Results:

  • Downregulation of pyroptosis is linked to cancer development.
  • Pyroptosis influences all stages of carcinogenesis.
  • GSDMD and GSDME play critical roles in cancer progression and regulation.

Conclusions:

  • Pyroptosis is a key factor in cancer biology.
  • Targeting pyroptosis presents a promising therapeutic strategy for cancer treatment.
  • Understanding GSDMD and GSDME functions is vital for cancer management.
Keywords:
CancerCaspase-1GSDMDGSDMENLRP3Pyroptosis

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