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Updated: Oct 22, 2025

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
Published on: February 16, 2017
The effects of tapentadol and oxycodone on central processing of tonic pain
Rasmus Bach Nedergaard1, Tine Maria Hansen2, Thomas Dahl Nissen3
1Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Objective:
The present study investigated differences between opioids to experimental tonic pain in healthy men.
Methods:
Twenty-one males participated in this cross-over-trial. Interventions twice daily were oxycodone (10 mg), tapentadol (50 mg) and placebo for 14 days. Tonic pain was induced on day 1, 4 and 14 by immersing the hand in 2 °C water for 120 s. Electroencephalography was recorded during test pain at baseline and after 14 days. Spectral analysis and source localization were investigated in predefined frequency bands.
Results:
A decreased perception of pain on day 4 persisted throughout the 14 days compared to baseline (p < 0.006). Oxycodone decreased the electroencephalography spectral power in the delta and theta bands and increased power in the alpha1, alpha2 and beta1 bands (p < 0.03). Tapentadol increased spectral power in the alpha1 band (p < 0.001). Source localization revealed that oxycodone decreased activity of the temporal and limbic region in the delta band, and frontal lobe in the alpha2 and beta1 bands, whereas tapentadol decreased alpha1 band activity in the temporal lobe compared to placebo.
Conclusion:
Oxycodone and tapentadol reduced pain perception and changed the central processing of tonic pain.
Significance:
Different mechanisms of action were involved, where oxycodone affected cortical structures more than tapentadol.
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