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Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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Deubiquitinases in hematological malignancies.

Hu Lei1, Jiaqi Wang2, Jiacheng Hu2

  • 1Department of Pathophysiology, International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. hulei@shsmu.edu.cn.

Biomarker Research
|August 29, 2021
PubMed
Summary
This summary is machine-generated.

Deubiquitinases (DUBs) are key enzymes in cell regulation and emerging therapeutic targets for blood cancers. Inhibitors targeting DUBs show promise in treating leukemia, multiple myeloma, and lymphoma.

Keywords:
DeubiquitinasesHematological malignanciesLeukemiaLymphomaMultiple myeloma

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Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Deubiquitinases (DUBs) regulate protein stability and function by removing ubiquitin tags.
  • Specific DUBs like USP7, USP9X, and USP10 are implicated as therapeutic targets in hematological malignancies.
  • DUBs exhibit diverse roles, acting as oncogenes, tumor suppressors, or having context-dependent effects in cancer.

Purpose of the Study:

  • To review the biological roles of DUBs in various hematological malignancies.
  • To summarize the development and application of DUB inhibitors in cancer therapy.
  • To highlight DUBs as potential therapeutic targets for blood cancers.

Main Methods:

  • Literature review of DUBs in hematological malignancies.
  • Summary of DUB inhibitor development and preclinical/clinical data.
  • Analysis of DUBs' roles in leukemia, multiple myeloma, and lymphoma.

Main Results:

  • DUBs play critical roles in the pathogenesis of hematological malignancies.
  • Potent DUB inhibitors have been developed with promising efficacy in preclinical models.
  • Several DUB inhibitors have advanced to clinical trials for blood cancers.

Conclusions:

  • DUBs represent a promising class of therapeutic targets for hematological malignancies.
  • Targeting DUBs offers a novel strategy for treating leukemia, multiple myeloma, and lymphoma.
  • Further exploration of DUBs' functions will uncover new therapeutic avenues in hematologic oncology.