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Updated: Oct 22, 2025

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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
84
Capacitance and transepidermal water loss after soaking in water for different durations: A pilot study
Rattanavalai Nitiyarom1, Tanyalak Withitanawanit1, Wanee Wisuthsarewong1
1Division of Dermatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Summary
Bathing duration did not significantly correlate with skin hydration (capacitance) or water loss (TEWL). However, a 5-minute soak optimally increased skin hydration in healthy individuals.
Area of Science:
- Dermatology
- Biophysics
- Skin Physiology
Background:
- Limited data exists on how bathing duration impacts skin properties.
- Understanding these effects is crucial for skin health and hygiene practices.
Purpose of the Study:
- To investigate the effects of varying water immersion durations on skin capacitance and transepidermal water loss (TEWL).
- To determine optimal bathing times for maintaining skin hydration and integrity.
Main Methods:
- A biophysical study involving healthy volunteers.
- Forearms were immersed in water for 3, 5, 10, 15, or 20 minutes.
- Skin hydration (capacitance) and integrity (TEWL) were measured before and after immersion.
Main Results:
- No significant correlation was found between bathing duration and changes in capacitance or TEWL.
- Skin capacitance peaked after 5 minutes of soaking but rapidly declined thereafter.
- TEWL showed a slight increasing trend with longer soaking durations, though not statistically significant.
Conclusions:
- Bathing duration does not significantly alter key cutaneous properties like capacitance and TEWL in healthy skin.
- A 5-minute soak appears to provide the most beneficial effect on skin hydration.
- Further research with larger sample sizes and additional physiological parameters is recommended.
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