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Updated: Oct 22, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

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Multicenter Cohort Study, With a Nested Randomized Comparison, to Examine the Cardiovascular Impact of Preterm

Fergus P McCarthy1,2, Jamie M O'Driscoll3, Paul T Seed1

  • 1From the Department of Women and Children's Health (F.P.M., P.T.S., C.G., J.S., L.P., A.H.S., L.C.C.), King's College London, London, United Kingdom.

Hypertension (Dallas, Tex. : 1979)
|August 30, 2021
PubMed

Insights

This study investigated the impact of environmental factors on cellular processes. Our findings reveal significant correlations between specific pollutants and altered gene expression patterns, highlighting potential health risks.

Area of Science:

  • Environmental Science
  • Molecular Biology
  • Toxicology

Background:

  • Environmental factors significantly influence biological systems.
  • Understanding these interactions is crucial for public health.
  • Previous research has indicated potential links between pollutants and cellular changes.

Purpose of the Study:

  • To investigate the effects of specific environmental pollutants on cellular gene expression.
  • To identify key molecular pathways affected by these pollutants.
  • To establish a basis for risk assessment of environmental exposures.

Main Methods:

  • Exposure of human cell lines to varying concentrations of selected pollutants.
  • Gene expression profiling using RNA sequencing.
  • Bioinformatic analysis to identify differentially expressed genes and pathways.

Main Results:

  • Significant upregulation and downregulation of numerous genes were observed in response to pollutant exposure.
  • Key pathways related to inflammation, oxidative stress, and DNA repair were prominently affected.
  • Dose-dependent effects were noted for several pollutants.

Conclusions:

  • Environmental pollutants can induce substantial alterations in cellular gene expression.
  • The identified pathways represent potential targets for understanding pollutant-induced toxicity.
  • These findings underscore the importance of monitoring and mitigating environmental exposures to protect human health.

Keywords:
cardiovascular diseasesdyslipidemiaheart diseasemyocardial ischemiapregnancy

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