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Related Concept Videos

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Viral Recombination00:57

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Urinary Tract Infection II: Pathophysiology01:25

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Updated: Oct 22, 2025

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
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Post-Operative Wound Infection by Multiple Zoonotic Organisms.

Matthew Albert1, Jesse P Wright1, Brandon Ocariz2

  • 1Advent Health Medical Group Colorectal Surgery at Orlando, Orlando, FL, USA.

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|August 30, 2021
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Summary
This summary is machine-generated.

This case report details a rare instance of simultaneous Rhodococcus hoagii and Pasteurella multocida infections in an immunocompromised patient. It highlights the diagnostic and management challenges of these zoonotic pathogens in a clinical setting.

Keywords:
Pasteurella multocidaRhodococcus hoagiipost-operative infectionzoonotic infection

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Immunocompromised Host

Background:

  • Rhodococcus hoagii (formerly Rhodococcus equi) and Pasteurella multocida are zoonotic bacteria.
  • R. hoagii is transmitted via inhalation of aerosols, while P. multocida is often associated with animal bites.
  • Both can cause severe systemic illness, particularly in immunocompromised individuals.

Purpose of the Study:

  • To describe the clinical course of a patient with co-infections of R. hoagii and P. multocida.
  • To highlight the diagnostic and management complexities of these rare zoonotic infections.
  • To emphasize the importance of considering zoonotic pathogens in immunocompromised patients with unusual presentations.

Main Methods:

  • Case report of a 42-year-old female patient.
  • Detailed review of the patient's medical history, including Crohn's disease and immunosuppressive therapy.
  • Documentation of the clinical presentation, diagnostic workup, and treatment of the identified infections.

Main Results:

  • The patient developed simultaneous infections with R. hoagii and P. multocida post-operatively.
  • The patient had a history of exotic animal exposure and was on immunosuppressive therapy for Crohn's disease.
  • Successful medical management of the complex, multi-microbial infections was achieved.

Conclusions:

  • This case underscores the potential for severe, systemic zoonotic infections in immunocompromised patients.
  • Early recognition and appropriate management are crucial for favorable outcomes.
  • Healthcare providers should maintain a high index of suspicion for zoonotic pathogens in at-risk populations.