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Upregulated Long Non-coding RNA ALMS1-IT1 Promotes Neuroinflammation by Activating NF-κB Signaling in Ischemic

Peng Lu1, Ye Zhang2, Huanjiang Niu1

  • 1Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, 310016, China.

Current Pharmaceutical Design
|August 30, 2021
PubMed
Summary

Inhibition of ALMS1-IT1, a brain-expressed lncRNA, improved neurological function in stroke models by reducing neuro-inflammation. This study highlights ALMS1-IT1 as a potential therapeutic target for ischemic cerebral damage.

Keywords:
ALMS1-IT1Ischemic cerebral injuryMCAONF-κBmNSS.neuro-inflammation

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