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Role of Patch Testing in Chronic Spontaneous Urticaria.
Jonathan Bar1, Sari Godlewicz2, Arieh Ingber2
1Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Journal of Asthma and Allergy
|August 30, 2021
Summary
Patch testing (PT) can help identify contact allergens in some chronic spontaneous urticaria (CSU) patients. Identifying and avoiding these allergens may resolve CSU symptoms, aiding diagnosis.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Chronic spontaneous urticaria (CSU) is a prevalent, disabling skin condition.
- Its primary mechanism involves autoimmune mast-cell degranulation.
- The role of patch testing (PT) in CSU diagnosis remains uncertain.
Purpose of the Study:
- To investigate the diagnostic utility of PT in patients with CSU.
- To compare PT results between CSU patients and a control group with suspected allergic contact dermatitis.
Main Methods:
- Retrospective analysis of patient cases undergoing patch testing.
- Comparison of PT outcomes in 134 CSU patients versus 680 controls.
Main Results:
- 3% of CSU patients showed relevant PT reactions, leading to symptom resolution upon allergen avoidance.
- Metals and textile dyes were identified as common allergens.
- No significant differences in positive PT rates or reaction profiles were observed between groups.
Conclusions:
- Patch testing can be a valuable tool for identifying specific triggers in some CSU cases.
- Allergen avoidance based on PT results can lead to symptom resolution.
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