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Updated: Oct 22, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Association Between Obstructive Sleep Apnea and Reduced Mortality in Critically Ill Patients: A Propensity
Ping Lin1, Xiaoqian Li1, Jiarui Zhang1
1Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Background:
The impact of obstructive sleep apnea (OSA) on the prognosis of intensive care unit (ICU) patients remains controversial. Thus, this study aimed to determine the association between OSA status and outcomes in ICU patients.
Methods:
We conducted a retrospective cohort study composed of 38,177 critically ill patients from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Propensity score matching was used to evaluate the association between OSA and mortality in ICU adults.
Results:
A total of 38,177 critically ill patients were included in this study. Among them, 1428 (3.71%) patients had OSA. Before matching, patients with OSA had a significantly lower 28-day mortality (relative risk (RR), 0.47; 95% confidence interval (CI), 0.38-0.58), 90-day mortality (RR, 0.50; 95% CI, 0.43-0.60), ICU mortality (RR, 0.41; 95% CI, 0.31-0.54), and in-hospital mortality (RR, 0.46; 95% CI, 0.36-0.57). After adjusting with propensity-score matching, the findings of reduced risk of mortality remained unchanged. The RR of 28-day mortality, 90-day mortality, ICU mortality, in-hospital mortality was 0.57 (95% CI, 0.34-0.57), 0.53 (95% CI, 0.40-0.70), 0.54 (95% CI, 0.37-0.79), and 0.55 (95% CI, 0.39-0.77), respectively.
Conclusion:
This study indicated that ICU patients with OSA had a significantly lower risk of mortality compared with those without OSA.
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