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Updated: Oct 22, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
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ANMCO POSITION PAPER: Prognostic and therapeutic relevance of non-obstructive coronary atherosclerosis

Giancarlo Casolo1, Domenico Gabrielli2, Furio Colivicchi3

  • 1Cardiology Department, Ospedale Versilia, Lido di Camaiore (LU), Via Aurelia 335, 55041 Lido di Camaiore, Italy.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|August 30, 2021
PubMed

Insights

Non-obstructive coronary artery disease (NobsCAD) indicates atherosclerosis without significant vessel narrowing. Recognizing NobsCAD is crucial for personalized preventive measures and improved patient prognosis beyond traditional risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Diagnostic Imaging

Background:

  • Atherosclerosis commonly affects the coronary arteries.
  • Non-obstructive coronary artery disease (NobsCAD) represents atherosclerosis without significant vessel narrowing.
  • NobsCAD has distinct prognostic implications, differentiating it from the absence of coronary atherosclerosis.

Purpose of the Study:

  • To emphasize the clinical significance of detecting and reporting non-obstructive coronary artery disease (NobsCAD).
  • To highlight the importance of distinguishing NobsCAD from the absence of coronary atherosclerosis.
  • To advocate for individualized treatment strategies based on NobsCAD assessment.

Main Methods:

  • Review of clinical data and diagnostic criteria for non-obstructive coronary artery disease (NobsCAD).
  • Analysis of prognostic value associated with NobsCAD detection.
  • Consideration of coronary angiogram findings (invasive and non-invasive) for NobsCAD assessment.

Main Results:

  • Non-obstructive coronary artery disease (NobsCAD) carries specific prognostic value.
  • Individualized preventive measures and treatment can be tailored based on NobsCAD severity and extent.
  • Assessing NobsCAD provides prognostic benefits beyond traditional cardiovascular risk factors.

Conclusions:

  • Non-obstructive coronary artery disease (NobsCAD) detection should prompt individualized preventive strategies.
  • Accurate reporting of NobsCAD is essential for patient management and prognostic assessment.
  • NobsCAD should not be confused with or ignored as trivial information.

Keywords:
AtherosclerosisCoronary artery diseaseCoronary atherosclerosisNon-obstructive CAD

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