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Asthma and COVID-19: Emphasis on Adequate Asthma Control
David D Nassoro1,2, Leodegard Mujwahuzi1,2, Issakwisa Habakkuk Mwakyula1,2
1Department of Internal Medicine, University of Dar Es Salaam, Mbeya College of Health and Allied Sciences, Mbeya, Tanzania.
Canadian Respiratory Journal
|August 30, 2021
Summary
Asthma patients face higher risks from respiratory viruses like SARS-CoV-2. Maintaining adequate asthma control, potentially with inhaled corticosteroids, may reduce severe COVID-19 outcomes and exacerbations.
Area of Science:
- Pulmonology
- Infectious Diseases
- Immunology
Background:
- Asthma patients are susceptible to respiratory viral infections, increasing exacerbation and pneumonia risk.
- Poorly controlled asthma and immune defects contribute to infection susceptibility.
- Glucocorticoids, particularly inhaled corticosteroids, are vital for asthma management.
Purpose of the Study:
- To review the impact of COVID-19 on asthma patients.
- To explore the role of asthma control and corticosteroids in SARS-CoV-2 infection outcomes.
Main Methods:
- Literature review and synthesis of current research on asthma, respiratory viruses, and COVID-19.
- Analysis of studies investigating corticosteroid efficacy in hospitalized COVID-19 patients with asthma.
Main Results:
- SARS-CoV-2 infection can worsen asthma exacerbations and chronic airway inflammation.
- Asthmatics often experience more severe COVID-19 clinical courses.
- Dexamethasone and inhaled corticosteroids show promise in reducing COVID-19 morbidity and mortality.
Conclusions:
- Adequate asthma control is crucial for mitigating severe outcomes from SARS-CoV-2 infection.
- Further high-level evidence studies are needed to fully elucidate the COVID-19-asthma relationship.
- Clinicians should prioritize asthma control to reduce exacerbation incidence and severity in the context of COVID-19.
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