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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Recent update on comprehensive therapy for advanced hepatocellular carcinoma
1Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
World Journal of Gastrointestinal Oncology
|August 30, 2021
Summary
Hepatocellular carcinoma (HCC) treatment has advanced, with systemic therapies like targeted therapy and immunotherapy improving outcomes for advanced stages. Combined approaches offer a new milestone in managing this common malignancy.
Area of Science:
- Oncology
- Hepatology
Background:
- Hepatocellular carcinoma (HCC) is a globally prevalent malignancy with high recurrence rates post-surgery.
- Most HCC diagnoses occur at advanced stages, precluding surgical resection.
Purpose of the Study:
- To review recent advancements in the systemic treatment of advanced Hepatocellular Carcinoma (HCC).
- To provide guidance for clinical practice in managing advanced HCC.
Main Methods:
- Literature review focusing on systemic therapies for advanced HCC.
- Analysis of multidisciplinary treatment strategies including targeted therapy and immunotherapy.
Main Results:
- Systemic treatment of advanced HCC has seen significant breakthroughs.
- Multidisciplinary approaches combining targeted therapy and immunotherapy are effective strategies.
Conclusions:
- Combined therapy has substantially improved Hepatocellular Carcinoma patient prognosis.
- Current treatment trends emphasize systemic and combined therapies for advanced HCC.
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