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Related Experiment Video

Updated: Oct 22, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

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Developing a normative database for retinal perfusion using optical coherence tomography angiography.

Bingyao Tan1,2,3, Yin Ci Sim3, Jacqueline Chua1,3,4

  • 1SERI-NTU Advanced Ocular Engineering (STANCE), Singapore.

Biomedical Optics Express
|August 30, 2021
PubMed
Summary

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This summary is machine-generated.

This study created an age-dependent normative database for 12x12 mm optical coherence tomography angiography (OCTA) images. This database helps characterize retinal perfusion abnormalities in ocular diseases like diabetic retinopathy and glaucoma.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Vascular Diseases

Background:

  • Optical coherence tomography angiography (OCTA) is crucial for understanding ocular diseases like glaucoma and diabetic retinopathy.
  • Current OCTA analysis faces challenges in quantifying peripheral retinal vascularity due to heterogeneous perfusion.
  • A normative OCTA database is needed to assess deviations from normal retinal perfusion.

Purpose of the Study:

  • To develop an age-dependent normative database for 12x12 mm OCTA images.
  • To enable quantitative assessment of retinal perfusion abnormalities.
  • To aid in the diagnosis and monitoring of ocular diseases.

Main Methods:

  • Acquired 12x12 mm OCTA images from 195 healthy subjects using a swept-source OCT system.

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Last Updated: Oct 22, 2025

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  • Employed U-Net for large blood vessel segmentation and a moving window scheme for capillary segmentation.
  • Corrected for anatomical factors like fovea-disc position.

    • Main Results:

    • Established an age-dependent normative database for 12x12 mm OCTA images across four age groups.
    • Demonstrated the database's utility in characterizing retinal perfusion in diabetic retinopathy and glaucoma patient groups.
    • Provided a quantitative tool for assessing retinal vascular abnormalities.

    Conclusions:

    • The developed age-dependent normative OCTA database facilitates the characterization of retinal perfusion abnormalities.
    • This database is valuable for assessing deviations from normal retinal vascularity in ocular pathologies.
    • The findings support the use of OCTA for quantitative analysis in clinical ophthalmology.