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Multiplex optical biosensors based on multi-pinhole interferometry.

Johannes Bläsi1, Martina Gerken1

  • 1Institute of Electrical Engineering and Information Technology, Kiel University, Kaiserstraße 2, 24143 Kiel, Germany.

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Summary

New optical sensor technology enables frequent biomarker monitoring for improved healthcare. This multi-analyte approach, using multi-pinhole interference, allows for point-of-care diagnostics and personalized therapy adjustments.

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Area of Science:

  • Biomedical Engineering
  • Optical Physics
  • Analytical Chemistry

Background:

  • Frequent biomarker monitoring is crucial for enhancing healthcare design and patient safety.
  • Artificial intelligence integration with sensor technology promises advanced point-of-care diagnostics.
  • Current limitations exist in simultaneously screening multiple biomarkers at the point of care.

Purpose of the Study:

  • To introduce a novel optical multiplexing approach for simultaneous biomarker detection.
  • To theoretically and experimentally validate a multi-pinhole interference technique for enhanced sensing.
  • To demonstrate the potential for real-time, multi-analyte health monitoring.

Main Methods:

  • Development of an optical multiplexing system utilizing multi-pinhole interference.
  • Theoretical analysis of 11-plex and 54-plex sensor designs.
  • Experimental validation using refractive index measurements and human alpha-thrombin detection.

Main Results:

  • Demonstrated inherent differential referencing across multiple measurement fields on a single surface.
  • Successfully performed 3-field refractive index measurements.
  • Achieved sensitive detection of human alpha-thrombin, validating the multiplexing capability.

Conclusions:

  • The proposed optical multiplexing technique offers a robust platform for high-throughput, point-of-care biomarker screening.
  • This technology has the potential to revolutionize personalized medicine through immediate therapeutic adjustments.
  • Further development could lead to advanced diagnostic tools for various health conditions.