Related Experiment Video
Updated: Oct 22, 2025

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy
Andreas Wartak1,2, Alfred K Kelada1, Paola A Leon Alarcon1
1Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Abstract:
OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system. The technology is validated in phantom experiments and feasibility is demonstrated in a methylene blue (MB)-stained swine esophageal injury model, ex vivo and in vivo.
Related Concept Videos
Endoscopic Procedures III: Video Capsule Endoscopy
Confocal Fluorescence Microscopy
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Total Internal Reflection Fluorescence Microscopy
Super-resolution Fluorescence Microscopy
Two-Dimensional Microscopy in Microbiology

