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Long-term release of copper from two multiload IUD models: MLCu250 and MLCu375
R H Drost1, M Thiery, R A Maes
1Center for Human Toxicology, State University, Utrecht, The Netherlands.
Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|December 1, 1987
Summary
This study assessed copper loss from two Multiload IUD types, finding both are effective long-lasting contraceptive agents. Copper loss rates suggest sustained efficacy for MLCu250 and MLCu375 devices.
Area of Science:
- Reproductive Health
- Materials Science
Background:
- Intrauterine devices (IUDs) are widely used reversible contraceptives.
- Copper IUDs release copper ions, providing a spermicidal effect and preventing pregnancy.
- Understanding copper release rates is crucial for determining IUD longevity and efficacy.
Purpose of the Study:
- To quantify the mean daily copper loss from two commercial Multiload IUD models.
- To evaluate the potential of these IUDs as long-lasting contraceptive methods based on copper release.
Main Methods:
- Analysis of copper content decrease in Multiload Copper 250 (MLCu250) and Multiload Copper 375 (MLCu375) IUDs.
- Calculation of mean daily copper loss for each IUD type.
Main Results:
- The mean daily copper loss was approximately 18 mcg for MLCu250 devices.
- The mean daily copper loss was approximately 30 mcg for MLCu375 devices.
Conclusions:
- Both MLCu250 and MLCu375 IUD models exhibit slow copper release rates.
- These findings support the classification of both Multiload IUD types as long-lasting contraceptive agents.