Related Experiment Video
Updated: Oct 22, 2025
Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
Published on: March 22, 2024
Risk Factors of Candida parapsilosis Catheter-Related Bloodstream Infection
Dina Hussein Yamin1, Azlan Husin2,3, Azian Harun1,3
1Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Abstract:
Catheter-related bloodstream infection (CRBSI) is an important healthcare-associated infection caused by various nosocomial pathogens. Candida parapsilosis has emerged as a crucial causative agent for the CRBSI in the last two decades. Many factors have been associated with the development of CRBSI including, demography, pre-maturity, comorbidities (diabetes mellitus, hypertension, heart diseases, neuropathy, respiratory diseases, renal dysfunction, hematological and solid organ malignancies, and intestinal dysfunction), intensive care unit (ICU) admission, mechanical ventilation (MV), total parenteral nutrition (TPN), prior antibiotic and/or antifungal therapy, neutropenia, prior surgery, immunosuppressant, and type, site, number, and duration of catheters. This study aims to determine C. parapsilosis CRBSI risk factors. A retrospective study has been performed in an 853-bedded tertiary-care hospital in north-eastern Malaysia. All inpatients with C. parapsilosis positive blood cultures from January 2006 to December 2018 were included, and their medical records were reviewed using a standardized checklist. Out of 208 candidemia episodes, 177 had at least one catheter during admission, and 31 cases had not been catheterized and were excluded. Among the 177 cases, 30 CRBSI cases were compared to 147 non-CRBSI cases [81 bloodstream infections (BSIs), 66 catheter colonizers]. The significance of different risk factors was calculated using multivariate analysis. Multivariate analysis of potential risk factors shows that ICU admission was significantly associated with non-CRBSI as compared to CRBSI [OR, 0.242; 95% CI (0.080-0.734); p = 0.012], and TPN was significantly positively associated with CRBSI than non-CRBSI [OR, 3.079; 95%CI (1.125-8.429); p = 0.029], while other risk factors were not associated significantly. Patients admitted in ICU were less likely to develop C. parapsilosis CRBSI while patients receiving TPN were more likely to have C. parapsilosis CRBSI when compared to the non-CRBSI group.
Insights
Catheter-related bloodstream infections (CRBSI) caused by Candida parapsilosis are linked to total parenteral nutrition (TPN). Intensive care unit (ICU) admission was found to be a protective factor against CRBSI.
Area of Science:
- Infectious Diseases
- Medical Mycology
- Hospital Epidemiology
Background:
- Catheter-related bloodstream infection (CRBSI) is a significant healthcare-associated infection.
- Candida parapsilosis has become a prominent cause of CRBSI in recent decades.
- Numerous factors contribute to CRBSI development, including patient demographics, comorbidities, and medical interventions.
Purpose of the Study:
- To identify specific risk factors associated with Candida parapsilosis CRBSI.
- To analyze the relationship between various clinical factors and the occurrence of C. parapsilosis CRBSI.
- To differentiate between CRBSI and catheter colonization by C. parapsilosis.
Main Methods:
- A retrospective study was conducted in a tertiary-care hospital in north-eastern Malaysia.
- Medical records of inpatients with C. parapsilosis positive blood cultures between January 2006 and December 2018 were reviewed.
- Multivariate analysis was employed to assess the significance of potential risk factors for CRBSI.
Main Results:
- Out of 208 candidemia episodes, 177 involved catheterized patients; 30 were CRBSI cases and 147 were non-CRBSI cases.
- Intensive care unit (ICU) admission was significantly associated with a lower likelihood of CRBSI (OR, 0.242; p = 0.012).
- Total parenteral nutrition (TPN) was significantly associated with a higher likelihood of CRBSI (OR, 3.079; p = 0.029).
Conclusions:
- Intensive care unit (ICU) admission appears to be a protective factor against Candida parapsilosis CRBSI.
- Total parenteral nutrition (TPN) is a significant risk factor for developing Candida parapsilosis CRBSI.
- Understanding these risk factors can aid in developing targeted prevention strategies for C. parapsilosis CRBSI.
More Related Videos
08:31Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
Published on: January 27, 2015
07:42An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:26Urine Studies II: Urine Culture and Sensitivity Test
01:25Urinary Tract Infection II: Pathophysiology
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications