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pH-Responsive DNA Motif: From Rational Design to Analytical Applications
Lin Lin Zheng1, Jin Ze Li1, Ying Xu Li1
1Shandong Province Key Laboratory of Detection Technology for Tumor Makers, Collaborative Innovation Center of Tumor Marker Detection Technology, School of Chemistry and Chemical Engineering, Feixian Campus, Linyi University, Linyi, China.
Abstract:
pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence of specific protonation sites. In this review, we briefly summarized second structure-based pH-responsive DNA motifs, including triplex DNA, i-motif, and A+-C mismatch base pair-based DNA devices. Finally, the challenges and prospects of pH-responsive DNA motifs are also discussed.
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