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Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators

Jian Zhang1,2, Huali Jiang3, Kunpeng Du1

  • 1Department of Radiation Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou, China.

Frontiers in Medicine
|August 30, 2021
PubMed

Insights

Genomic alterations in COVID-19 receptor regulators are widespread in 33 cancers, correlating with cancer pathways and offering potential prognostic biomarkers and novel therapeutic targets.

Area of Science:

  • Oncology
  • Virology
  • Genomics

Background:

  • Cancer patients face poorer outcomes with COVID-19.
  • The role of COVID-19 receptor regulators in cancer remains unclear.
  • Comprehensive analysis of these regulators in tumorigenesis is lacking.

Purpose of the Study:

  • To evaluate genomic alterations of six COVID-19 receptor regulators in solid tumors.
  • To investigate the clinical relevance and prognostic potential of these regulators.
  • To identify potential drug targets for cancer treatment.

Main Methods:

  • Analysis of TCGA data (RNA-seq, SNV, CNV, methylation, miRNA-mRNA networks) across 33 solid tumors.
  • Evaluation of genomic alterations in transmembrane serine protease 2 (TMPRSS2), angiotensinogen (AGT), angiotensin-converting enzyme 1 (ACE1), solute carrier family 6 member 19 (SLC6A19), angiotensin-converting enzyme 2 (ACE2), and angiotensin II receptor type 2 (AGTR2).
  • Assessment of drug sensitivities targeting these regulators using the Cancer Therapeutics Response Portal.

Main Results:

  • Widespread genetic alterations in COVID-19 receptor regulators were identified across 33 cancer types.
  • Expression levels of these regulators significantly correlated with cancer hallmark pathways.
  • Potential prognostic biomarkers and novel drug targets were discovered.

Conclusions:

  • Genomic alterations and clinical characteristics of COVID-19 receptor regulators in 33 cancers were elucidated.
  • These findings may clarify mechanisms linking these regulators to tumorigenesis.
  • This study offers a novel therapeutic approach for cancer treatment.
Keywords:
COVID-19 regulatorsgenetic alterationsmethylationpan-cancerprognosis

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