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Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
Chloé Girard1,2, Chantal C Akerib1, Anne M Villeneuve1
1Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, U.S.A.
Abstract:
Meiotic crossover formation requires the activity of multiple pro-crossover factors, including the MutSγ complex and the cyclin-related protein COSA-1, that become concentrated together at the sites of crossover recombination intermediates. Here we show that a transgene insertion expressing GFP::COSA-1 can suppress the crossover deficit caused by a partial reduction in MutSγ function. Our data, combined with previous findings, support a model in which COSA-1 promotes crossover formation, at least in part, through positive regulation of MutSγ function.
