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Updated: Oct 22, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Harnessing cyclotides to design and develop novel peptide GPCR ligands

Edin Muratspahić1,2, Johannes Koehbach2, Christian W Gruber1

  • 1Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna Austria christian.w.gruber@meduniwien.ac.at.

RSC Chemical Biology
|August 30, 2021
PubMed
Summary

Engineered cyclotides offer stable scaffolds for developing new peptide therapeutics targeting G protein-coupled receptors (GPCRs). Molecular grafting enhances their pharmacokinetic properties, making them valuable tools for drug discovery and studying GPCR signaling.

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