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Sulfites and skin pathology in children
J Botey1, M Cozzo, J L Eseverri
1Servicio de Alergia e Inmunologia Clinica, Hospital Infantil Valle de Hebron, Universidad Autonoma de Barcelona, Spain.
Allergologia Et Immunopathologia
|November 1, 1987
Summary
Eight children experienced urticaria and angioedema due to sodium bisulfite hypersensitivity. Oral provocation tests confirmed this allergy, with reactions appearing shortly after or delayed following specific doses.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Nutrition
- Food Additive Research
Background:
- Urticaria and angioedema are common allergic reactions in children.
- Food additives are potential triggers for such reactions.
- Sodium bisulfite is a widely used preservative that may cause hypersensitivity.
Purpose of the Study:
- To investigate the role of sodium bisulfite in pediatric urticaria and angioedema.
- To identify hypersensitivity to sodium bisulfite in children presenting with allergic skin reactions.
Main Methods:
- Case study involving 8 children aged 2-7 years with urticaria/angioedema.
- Allergy assessment through an additives study based on habitual dietary programs.
- Oral provocation testing with controlled doses (5 mg and 25 mg) of sodium bisulfite.
Main Results:
- Sodium bisulfite hypersensitivity was confirmed in the studied pediatric population.
- Positive reactions occurred within one hour or were delayed after the second dose.
- Two cases exhibited semi-delayed reactions to sodium bisulfite.
- No respiratory symptoms were observed in any of the children.
Conclusions:
- Sodium bisulfite can be a trigger for urticaria and angioedema in susceptible children.
- Oral provocation testing is effective in diagnosing sodium bisulfite hypersensitivity.
- Further research into food additive allergies in pediatric populations is warranted.