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Clinicopathological features of cutaneous reactions after mRNA-based COVID-19 vaccines
M Tihy1, S Menzinger1,2, R André2
1Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
Background:
Cutaneous reactions, mostly on injection site after mRNA-based COVID-19 vaccines, have been reported but not with detailed histopathological characterization.
Objectives:
Characterization and classification of these reactions in a clinical and pathological point of view.
Methods:
Monocentric case series of 11 patients with cutaneous manifestations, clinically and histologically characterized after COVID-19 vaccination.
Results:
From January to June 2021, we recorded 11 cutaneous reactions to mRNA COVID-19 vaccines from BNT162b2 (n = 8) and mRNA-1273 (n = 3). Generalized reactions showing erythematous rash or purpura were the most common clinical presentation, and drug-reaction-like pattern was the most common histological finding.
Conclusions:
A proper clinicopathological classification will be helpful in the early diagnosis and management of the cutaneous reactions to mRNA COVID-19 vaccines.
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