[Effects of parameters selection with transcranial direct current stimulation based on real head model]

Area of Science:

• Neuroscience
• Biomedical Engineering
• Computational Modeling

Background:

• Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique.
• Current selection criteria for tDCS stimulation parameters lack standardization.
• Optimizing tDCS parameters is crucial for effective therapeutic outcomes.

Purpose of the Study:

• To analyze the impact of stimulation parameters on electric field distribution in the brain using a realistic head model.
• To determine optimal electrical stimulation parameters for tDCS.
• To provide a basis for selecting effective tDCS parameters.

Main Methods:

• Construction of a four-layer finite element real head model.
• Simulation of electric field distribution by varying current intensity, electrode shape, area, and spacing.
• Analysis of changes in effective stimulation region and focusing ability.

Main Results:

• Increased current intensity reduced the effective stimulation region but enhanced focusing ability.
• Quadrilateral electrodes demonstrated higher normal current density and more concentrated effective stimulation compared to circular electrodes.
• Optimal electrode spacing for enhanced focusing was determined to be between 64.0-67.2 mm.

Conclusions:

• Electrode shape and spacing significantly influence tDCS electric field distribution and focusing.
• Quadrilateral electrodes are more effective for neuronal stimulation than circular ones.
• The findings offer guidance for selecting optimal tDCS parameters to improve stimulation efficacy.