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The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers

Qi Zhang1, Yinxin Wu1, Jinlan Chen1

  • 1College of Medical Science, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|August 30, 2021
PubMed
Abstract

Insights

Muscleblind-like-protein 1 (MBNL1) and its antisense protein MBNL1-AS1 regulate tumor growth and metastasis. Their altered expression in various cancers suggests potential as therapeutic targets for cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Metabolism

Background:

  • Muscleblind-like-proteins (MBNL) are key regulators of RNA splicing, crucial for muscle and neuron differentiation.
  • MBNL1 inactivation is linked to myotonic dystrophy and associated symptoms.
  • MBNL1 and MBNL1-AS1 play significant roles in tumor progression and metastasis.

Purpose of the Study:

  • To review the role of MBNL1 and MBNL1-AS1 in cancer pathogenesis.
  • To identify MBNL1 and MBNL1-AS1 as potential therapeutic targets for cancer treatment.

Main Methods:

  • Systematic retrieval of correlated research via PubMed.
  • Analysis of the roles of MBNL1 and MBNL1-AS1 in tumor development.

Main Results:

  • MBNL1 is down-regulated in breast, leukemia, stomach, esophageal cancers, and glioma, impairing its anti-metastatic function.
  • MBNL1 is up-regulated in cervical and colorectal cancers, promoting tumor development.
  • MBNL1-AS1 inhibits proliferation and metastasis in colorectal, non-small cell lung, and gastric cancers.

Conclusions:

  • MBNL1 is a critical regulator of tumor metastasis and growth.
  • MBNL1 and MBNL1-AS1 represent promising therapeutic targets for various cancers.
  • Further exploration of MBNL1's therapeutic potential is warranted.
Keywords:
MBNL1MBNL1-AS1inhibitory factorinvasionmigrationproliferationtumor

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