Related Experiment Video
Updated: Oct 22, 2025
11:36
A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
9.5K
THE ROLE OF CIRCADIAN REGULATION OF GHRELIN LEVELS IN PARKINSON'S DISEASE (LITERATURE REVIEW)
Kateryna A Tarianyk1, Nataliya V Lytvynenko1, Anastasiia D Shkodina1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|August 30, 2021
Summary
Circadian regulation of ghrelin, the hunger hormone, may be altered in Parkinson's disease, potentially impacting eating behaviors and metabolic health. Further research into ghrelin's role could offer new therapeutic strategies.
Area of Science:
- Neuroscience
- Endocrinology
- Chronobiology
Background:
- Parkinson's disease (PD) is characterized by diurnal fluctuations in motor and non-motor symptoms.
- These fluctuations are linked to alterations in biological rhythms and dopaminergic neurotransmission.
- The circadian system, crucial for regulating daily rhythms, is known to be disrupted in PD.
Purpose of the Study:
- To analyze the role of circadian regulation of ghrelin levels in Parkinson's disease.
- To investigate the potential of ghrelin as a biomarker for PD.
- To explore ghrelin's influence on eating behavior and metabolic disorders in PD patients.
Main Methods:
- Literature review and analysis of existing data on circadian rhythms, ghrelin, and Parkinson's disease.
- Examination of the link between clock genes, ghrelin expression, and food-entrainable rhythms.
- Correlation of ghrelin fluctuations with diurnal symptom variations and dopaminergic therapy efficacy.
Main Results:
- Circadian system alterations in PD may lead to changes in ghrelin fluctuations.
- Ghrelin, influenced by clock genes, might act as a food-entrainable oscillator.
- Altered ghrelin levels in PD could contribute to changes in eating behavior and metabolic disturbances.
Conclusions:
- Ghrelin's altered circadian regulation in Parkinson's disease warrants further investigation.
- Ghrelin may serve as a potential biomarker for Parkinson's disease.
- Understanding ghrelin's role and its diurnal variations could inform treatment strategies for PD, including optimizing levodopa therapy.
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:37Neural Regulation
40.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.6K
01:15Parkinson's Disease: Overview
887
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
887
01:24Parkinson's Disease: Treatment
469
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
469
01:30Regulation of Food Intake
1.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
1.0K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
170
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
170