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Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
11:11

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Evidence-Based Recommendations for Nurse Monitoring and Management of Immunotherapy-Induced Cytokine Release

Emily K Browne1, Emily Daut2, Monica Hente2

  • 1Transition Oncology Program, 547309St. Jude Children's Research Hospital, Memphis, TN, USA.

Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses
|August 30, 2021
PubMed

Children with B-precursor acute lymphoblastic leukemia and B-cell lymphoma, particularly those with relapsed or refractory disease, are increasingly enrolled on phase II and phase III clinical trials studying immunotherapies. These therapeutic agents may be associated with a high risk of cytokine release syndrome (CRS), and nurses lack standardized guidelines for monitoring and managing patients with CRS. Six studies and one clinical practice guideline were included in this systematic review that examined the evidence of CRS following administration of chimeric antigen receptor T-cell therapy or the bi-specific T-cell engager antibody, blinatumomab. Six nursing practice recommendations (five strong, one weak) were developed based on low or very low-quality evidence: three reflect preinfusion monitoring, one focuses on monitoring during and postinfusion, and three pertain to the nurse's role in CRS management.

Keywords:
chimeric antigen receptor T-cell therapycytokinesguidelinesimmunotherapy

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