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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

274
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
274
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

210
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
210
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

146
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
146
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

176
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
176
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

96
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
96
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

97
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
97

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Related Experiment Video

Updated: Oct 22, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

443

Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD.

Eric H Au1, Germaine Wong1, Kirsten Howard2

  • 1Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia; Centre for Transplant and Renal Research, Westmead Hospital, Westmead, Australia.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|August 30, 2021
PubMed
Summary

Older age, male sex, and use of erythropoiesis-stimulating agents and azathioprine are linked to advanced colorectal neoplasia in chronic kidney disease (CKD) patients. These findings aid in understanding cancer risk in CKD populations.

Keywords:
Azathioprinebowel cancerchronic kidney disease (CKD)colonoscopycolorectal cancerdialysisend-stage renal disease (ESRD)epidemiologyfecal immunochemical test (FIT)risk factorstransplant recipient

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Area of Science:

  • Nephrology
  • Gastroenterology
  • Oncology

Background:

  • Patients with chronic kidney disease (CKD) have double the risk of colorectal cancer.
  • Factors contributing to colorectal cancer in CKD patients are not well understood.

Purpose of the Study:

  • To identify factors associated with advanced colorectal neoplasia in patients with CKD stages 3-5.
  • To investigate associations in patients undergoing maintenance dialysis or kidney transplantation.

Main Methods:

  • A prospective cohort study involving 1,706 patients across 11 international sites.
  • Screening for colorectal neoplasia using fecal immunochemical test (FIT) followed by colonoscopy.
  • Multivariable logistic regression and grouped LASSO logistic regression analyzed associations.

Main Results:

  • 117 patients (6.9%) had advanced colorectal neoplasia, including 9 colorectal cancers.
  • Factors associated with advanced colorectal neoplasia included older age (OR 1.05), male sex (OR 2.27), azathioprine use (OR 2.99), and erythropoiesis-stimulating agent use (OR 1.92).
  • Sensitivity analyses confirmed these associations.

Conclusions:

  • Older age, male sex, azathioprine, and erythropoiesis-stimulating agents are significantly associated with advanced colorectal neoplasia in CKD patients.
  • Further research is needed to address unmeasured confounding factors.