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Temperature-responsive biodegradable injectable polymers with tissue adhesive properties.

Soichiro Fujiwara1, Yuta Yoshizaki2, Akinori Kuzuya3

  • 1Faculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan.

Acta Biomaterialia
|August 30, 2021
PubMed
Summary

Injectable polymers were enhanced with aldehyde-modified Pluronic (PL-CHO) for improved tissue adhesion. This modification offers controllable adhesion for vascular embolization and effective postoperative adhesion prevention in vivo.

Keywords:
Biodegradable polymersInjectable hydrogelsTemperature-responsiveTissue adhesionVascular embolization

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Injectable polymers (IPs) forming in situ hydrogels are promising for vascular embolization and adhesion prevention.
  • Controllable tissue adhesion and sustained in vivo gel state are critical for IP efficacy.
  • Previous IPs utilized triblock copolymers (tri-PCGs) with temperature-responsive gelation and covalent cross-linking.

Purpose of the Study:

  • To enhance injectable polymer systems with controllable tissue adhesive properties.
  • To improve vascular embolization and postoperative adhesion prevention capabilities of existing IPs.
  • To investigate the role of aldehyde groups in modulating IP tissue interactions.

Main Methods:

  • Modification of Pluronic with aldehyde groups (PL-CHO) to create a new IP component.
  • Mixing PL-CHO with a previously developed tri-PCG-Acryl based IP system.
  • Evaluation of tissue adhesion properties via Schiff base formation.
  • Assessment of vascular embolization performance in vitro.
  • Testing of in vivo adhesion prevention efficacy in the abdominal space.

Main Results:

  • The addition of PL-CHO conferred controllable tissue adhesive properties to the IPs through Schiff base formation.
  • Adhesion strength was directly tunable by varying the concentration of PL-CHO.
  • IPs containing PL-CHO demonstrated improved vascular embolization performance and pressure resistance.
  • The hydrogel maintained its integrity in vivo for 2 days, showing effective postoperative adhesion prevention.

Conclusions:

  • Mixing injectable polymers with aldehyde-modified Pluronic (PL-CHO) effectively introduces tunable tissue adhesion.
  • This strategy significantly enhances vascular embolization capabilities and in vivo performance for adhesion prevention.
  • The developed system offers a promising solution for medical applications requiring controlled tissue integration and retention.