Impulsivity is related to overhasty risk learning in attention-deficit/hyperactivity disorder: A computational...

Attention-deficit/hyperactivity disorder (ADHD) is often accompanied by excessive risky behavior, and an impulsive trait has been proposed to be associated with risk-taking. However, the aspect of the cognitive process that impulsivity influences is not well understood. We hypothesized that impulsivity could be related to an overhasty shifting of beliefs during risk learning, thereby resulting in enhanced risk-taking behavior. In this study, we tested our hypothesis using the Bayesian modeling approach and predicted overhasty learning by a data-driven approach. We used an openly available task-based functional magnetic resonance imaging (fMRI) dataset. Participants with adult ADHD (n = 42) completed the balloon analog risk task (BART). By fitting our computational model that encapsulates the degree of overhasty learning, we estimated the degree of learning bias and investigated its relationship with Barratt Impulsiveness Scale (BIS) outcomes. Moreover, we created a connectome-based predictive model (CPM) based on fMRI data to predict the degree of risk-learning bias. The degree of overhasty learning in ADHD patients was significantly correlated with the BIS score (r = 0.424, p = 0.009). The CPM predicted the 'learning bias' parameter using negatively correlated edges (r = 0.341, p = 0.041; q² = 0.092). The 'hub nodes' in the predictive network were in the frontal lobe, including the orbitofrontal area. Our findings suggest that impulsivity in ADHD patients is associated with overhasty updating of beliefs during risk learning. Weak functional connectivity to the both dorso-lateral prefrontal and orbitofrontal lobes is predictive of the degree of overhasty learning.