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The regulatory role of antisense lncRNAs in cancer

Biao Liu1, Wei Xiang1, Jiahao Liu1

  • 1Department of Urology, The Third Xiangya Hospital of Central South University, No.138, Tongzipo Road, Changsha, 410013, Hunan, China.

Cancer Cell International
|August 31, 2021
PubMed

Insights

Antisense long non-coding RNAs (lncRNAs) are key regulators in cancer development, influencing cell growth, spread, and treatment response. These molecules offer potential as diagnostic markers and therapeutic targets for cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Antisense long non-coding RNAs (lncRNAs) are transcribed from the opposite strand of protein-coding or non-coding genes.
  • These molecules have emerged as critical players in tumor onset and progression.

Purpose of the Study:

  • To review the functions and molecular mechanisms of antisense lncRNAs in cancer.
  • To discuss their potential as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review and synthesis of existing research on antisense lncRNAs in cancer.
  • Analysis of functional roles and regulatory mechanisms.

Main Results:

  • Antisense lncRNAs can promote or suppress cancer cell proliferation, migration, invasion, and chemoradiosensitivity.
  • They exert regulatory functions via epigenetic, transcriptional, post-transcriptional, and translational modulations.
  • Antisense lncRNAs play a unique role in regulating their corresponding sense genes due to sequence complementarity.

Conclusions:

  • Antisense lncRNAs are crucial regulators in cancer tumorigenesis and progression.
  • They hold significant potential for development as cancer diagnostic biomarkers and therapeutic targets.
Keywords:
Antisense lncRNACancerTarget therapyTranscriptional modulationTranslational control

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