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Updated: Oct 22, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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[Pathology and Mechanisms Underlying Thrombus Formation in Stroke]
Atsushi Yamashita1, Yujiro Asada
1Department of Pathology, Faculty of Medicine, University of Miyazaki.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|August 31, 2021
Summary
Atherothrombosis and cardiac thrombus involve complex mechanisms. von Willebrand factor (VWF) and fibrin are key in platelet adhesion and occlusive thrombus formation, while Factor XI is a target for anticoagulants.
Area of Science:
- Cardiovascular Biology
- Thrombosis Research
Background:
- Atherothrombosis and cardiac thrombus formation are complex processes.
- Ischemic stroke involves large thrombus formation and vascular occlusion.
- Plaque disruption and thrombogenicity dictate atherothrombus size.
Purpose of the Study:
- To elucidate the mechanisms of atherothrombus and cardiac thrombus formation.
- To highlight the roles of specific factors in thrombus development.
- To identify potential targets for anticoagulant therapies.
Main Methods:
- Review of mechanisms of atherothrombosis and cardiac thrombus.
- Analysis of the roles of von Willebrand factor (VWF), fibrin, and tissue factor.
- Examination of shear stress effects and atrial fibrillation's contribution.
Main Results:
- Tissue factor drives thrombin generation, fibrin formation, and platelet aggregation.
- von Willebrand factor (VWF) and fibrin act as scaffolds for platelet adhesion on ruptured plaques.
- Changes in shear stress and atrial fibrillation contribute to thrombus formation and elevated VWF and fibrinogen.
Conclusions:
- von Willebrand factor (VWF) and fibrin are crucial for initial platelet adhesion and occlusive thrombus.
- Coagulation Factor XI plays a significant role in thrombus growth, making it a target for anticoagulants.
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