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Related Experiment Video

Updated: Oct 22, 2025

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Published on: February 19, 2018

Programming ultrasensitive threshold response through chemomechanical instability.

Young-Joo Kim¹, Junho Park², Jae Young Lee²

¹Institute of Advanced Machines and Design, Seoul National University, Seoul, Korea.

Nature Communications

|August 31, 2021

Summary

This summary is machine-generated.

Scientists created a new chemomechanical method for ultrasensitive molecular switches using DNA origami. This approach mimics biological systems, offering controllable threshold responses in synthetic structures.

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Area of Science:

Biochemistry
Molecular Engineering
Nanotechnology

Background:

Ultrasensitive threshold responses are common in biological systems.
Creating controllable ultrasensitivity in synthetic molecular structures is difficult.

Purpose of the Study:

To develop a chemomechanical approach for achieving controllable ultrasensitivity in synthetic molecular structures.
To utilize Michell's instability for creating a molecular switch.

Main Methods:

Constructing molecular rings using DNA origami.
Inducing torsional stress in DNA rings with DNA intercalators.
Observing reconfiguration triggered by critical stress levels.

Main Results:

Successfully demonstrated Michell's instability in synthetic DNA rings.
Achieved ultrasensitive threshold reconfiguration at a critical intercalator concentration.
Showcased control over the critical point and sensitivity by altering ring design.

Conclusions:

The proposed chemomechanical approach effectively creates controllable ultrasensitive threshold responses in synthetic molecular structures.
DNA origami and Michell's instability provide a viable platform for designing molecular switches with tunable properties.