Tailored Chiral Copper Selenide Nanochannels for Ultrasensitive Enantioselective Recognition and Detection

We constructed a tailorable membrane channel system consisting of penicillamine molecules intercalated in copper selenide nanoparticles (Cu_2-x Se NPs), which exhibited circular dichroism (CD) bands in the near infrared region (CD, 800-1600 nm) with a maximum intensity of 164.5 mdeg at 1440 nm. The chiral ligand hybridized to the surface of achiral Cu_2-x Se NPs by breaking the intrinsic symmetry of Cu_2-x Se NPs and further large-scale assembly induced strong optical activity. The fabricated multilayer chiral membrane achieved an increased rectification ratio (RR) up to 114. The integration of penicillamine allowed for high enantioselective recognition against naproxen,which displayed high sensitivity with a limit of detection (LOD) as low as 0.027 nM.