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Updated: Oct 22, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

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The infinite possibilities of RNA therapeutics

Evelyn C Mollocana-Lara1, Ming Ni2, Spiros N Agathos3

  • 1School of Biological Sciences and Engineering, Yachay Tech University, 100119, San Miguel de Urcuquí, Ecuador.

Journal of Industrial Microbiology & Biotechnology
|August 31, 2021
PubMed

Insights

RNA therapeutics, including mRNA and siRNA, are rapidly advancing due to their role in cell regulation and disease. This review covers RNA types, manufacturing, delivery, approved therapies, and future potential for personalized medicine.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • RNA therapeutics research, initially overshadowed by DNA therapies, has resurged due to a deeper understanding of RNA's role in cellular regulation and disease.
  • Key RNA types like messenger RNA (mRNA), antisense oligonucleotides (ASOs), aptamers, small interfering RNAs (siRNAs), and microRNAs (miRNAs) are central to this field.

Purpose of the Study:

  • To provide a comprehensive overview of current RNA therapeutic modalities.
  • To review the state-of-the-art in synthetic RNA manufacturing and delivery technologies.
  • To summarize FDA-approved RNA-based therapies and ongoing clinical trials.

Main Methods:

  • Literature review of RNA therapeutic molecules and technologies.
  • Analysis of FDA-approved RNA-based drugs and clinical trial data.
  • Discussion of manufacturing and delivery advancements.

Main Results:

  • Identified key RNA molecules (IVT mRNA, ASOs, aptamers, siRNAs, miRNAs) utilized in therapeutics.
  • Detailed current technologies for synthetic RNA production and delivery systems.
  • Cataloged FDA-approved RNA therapies and highlighted active clinical investigations.

Conclusions:

  • RNA therapeutics offer significant advantages, including potential for personalized medicine and broader accessibility.
  • The field is poised to revolutionize healthcare through innovative RNA-based treatment strategies.
  • Continued research in RNA manufacturing and delivery will accelerate therapeutic development.
Keywords:
Antisense oligonucleotideAptamerIVT mRNARNA therapeuticsmiRNA

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